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1

Squalene-derived flexible linkers for bioactive peptides

Bhumasamudram Jagadish, Rajesh Sankaranarayanan, Liping Xu, Reyniak Richards, Josef Vagner, Victor J. Hruby, Robert J. Gillies, Eugene A. Mash

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 171 KB

english, 2007

2

Philosophy and results of breeding endangered species at Dvur Kralove n.l.

Journal:

International Zoo Yearbook

Year:

1980

Language:

english

File:

PDF, 323 KB

english, 1980

3

Hitting multiple targets with multimeric ligands

Handl, Heather L, Vagner, Josef, Han, Haiyong, Mash, Eugene, Hruby, Victor J, Gillies, Robert J

Journal:

Expert Opinion on Therapeutic Targets

Year:

2004

Language:

english

File:

PDF, 533 KB

english, 2004

4

Neuroligin 2 regulates spinal GABAergic plasticity in hyperalgesic priming, a model of the transition from acute to chronic pain

Kim, Ji-Young V., Megat, Salim, Moy, Jamie K., Asiedu, Marina N., Mejia, Galo L., Vagner, Josef, Price, Theodore J.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.12 MB

english, 2016

5

Heterobivalent Ligands Crosslink Multiple Cell-Surface Receptors: The Human Melanocortin-4 and δ-Opioid Receptors

Josef Vagner, Liping Xu, Heather L. Handl, Jatinder S. Josan, David L. Morse, Eugene A. Mash, Robert J. Gillies, Victor J. Hruby

Journal:

Angewandte Chemie

Year:

2008

Language:

english

File:

PDF, 423 KB

english, 2008

6

Heterobivalent Ligands Crosslink Multiple Cell-Surface Receptors: The Human Melanocortin-4 and δ-Opioid Receptors

Josef Vagner, Liping Xu, Heather L. Handl, Jatinder S. Josan, David L. Morse, Eugene A. Mash, Robert J. Gillies, Victor J. Hruby

Journal:

Angewandte Chemie International Edition

Year:

2008

Language:

english

File:

PDF, 423 KB

english, 2008

7

Opioid and melanocortin receptors: Do they have overlapping pharmacophores?

Yeon Sun Lee, Richard S. Agnes, James P. Cain, Vinod Kulkarni, Minying Cai, Christine Salibay, Kathy Ciano, Ravil Petrov, Alexander Mayorov, Josef Vagner, Dev Trivedi, Peg Davis, Shou-wu Ma, Josephine

Journal:

Year:

2008

Language:

english

File:

PDF, 159 KB

english, 2008

8

Intelligent Design in Combinatorial Chemistry: Use of Designed Peptide Libraries to Explore Secondary and Tertiary Structures in Peptides and Proteins

Scott M. Cowell, Xuyuan Gu, Josef Vagner, Victor J. Hruby

Journal:

Year:

2005

File:

PDF, 59 KB

2005

9

Range of HPV 16 E7 antibodies in cervical cancer patients, and healthy subjects

Alena Suchánková, Martin Krčmář, Viktor Krchňák, Eva Hamšíková, Jir̂ar, Kaňka, Josef Vágner, Vladimír Vonka

Journal:

International Journal of Cancer

Year:

1992

Language:

english

File:

PDF, 170 KB

english, 1992

10

A general procedure for evaluation of immunological relevance of synthetic peptides: Peptides synthesized on paper in enzyme-linked immunosorbent assay

Viktor Krchňák, Josef Vágner, Jan Novák, Alena Suchánková, Jaroslav Roubal

Journal:

Analytical Biochemistry

Year:

1990

Language:

english

File:

PDF, 428 KB

english, 1990

11

Synthesis and characterization of a Eu-DTPA-PEGO-MSH(4) derivative for evaluation of binding of multivalent molecules to melanocortin receptors

Liping Xu, Josef Vagner, Ramesh Alleti, Venkataramanarao Rao, Bhumasamudram Jagadish, David L. Morse, Victor J. Hruby, Robert J. Gillies, Eugene A. Mash

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 298 KB

english, 2010

12

Development of a lanthanide-based assay for detection of receptor–ligand interactions at the δ-opioid receptor

Heather L. Handl, Josef Vagner, Henry I. Yamamura, Victor J. Hruby, Robert J. Gillies

Journal:

Analytical Biochemistry

Year:

2005

Language:

english

File:

PDF, 269 KB

english, 2005

13

Optimization of time-resolved fluorescence assay for detection of europium–tetraazacyclododecyltetraacetic acid-labeled ligand–receptor interactions

Channa R. De Silva, Josef Vagner, Ronald Lynch, Robert J. Gillies, Victor J. Hruby

Journal:

Analytical Biochemistry

Year:

2010

Language:

english

File:

PDF, 577 KB

english, 2010

14

Peptidomimetics, a synthetic tool of drug discovery

Josef Vagner, Hongchang Qu, Victor J Hruby

Journal:

Current Opinion in Chemical Biology

Year:

2008

Language:

english

File:

PDF, 380 KB

english, 2008

15

Design, synthesis, and validation of rigid linkers for bioactive peptides

Yasunari Monguchi, Josef Vagner, Heather L. Handl, Umasish Jana, Lucinda J. Begay, Victor J. Hruby, Robert J. Gillies, Eugene A. Mash

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 167 KB

english, 2005

16

Oligomerization of fluorinated 2-butenamides and 2-butenoates by sodium tetrahydroborate

Václav Dědek, František Liška, Jiří Fikar, Milan Bárta, Marie Kašparová, Richard Hrabal, Zdeněk Sedláček, Josef Vágner

Journal:

Journal of Fluorine Chemistry

Year:

1985

File:

PDF, 43 KB

1985

17

A solid phase traceless synthesis of quinoxalinones

Viktor Krchňák, Lajos Szabo, Josef Vágner

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 158 KB

english, 2000

18

A solid phase traceless synthesis of 2-arylaminobenzimidazoles

Viktor Krchňák, Jennifer Smith, Josef Vágner

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 100 KB

english, 2001

19

Continuous-flow solid-phase peptide synthesis

Viktor Krchňák, Josef Vágner, Martin Flegel, Otakar Mach

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 265 KB

english, 1987

20

A solid-phase traceless synthesis of tetrahydroquinoxalines

Viktor Krchňák, Jennifer Smith, Josef Vágner

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 89 KB

english, 2001

21

Abscisic acid, polyamines and phenolic acids in sessile oak somatic embryos in relation to their conversion potential

Milena Cvikrová, Jana Malá, Josef Eder, Marie Hrubcová, Martin Vágner

Journal:

Plant Physiology and Biochemistry

Year:

1998

Language:

english

File:

PDF, 934 KB

english, 1998

22

Effect of inhibition of phenylalanine ammonia-lyase activity on growth of alfalfa cell suspension culture: Alterations in mitotic index, ethylene production, and contents of phenolics, cytokinins and polyamines

Milena Cvikrová, Pavla Binarová, Josef Eder, Martin Vágner, Marie Hrubcová, Jerzy Zoń, Ivana Macháčková

Journal:

Physiologia Plantarum

Year:

1999

Language:

english

File:

PDF, 617 KB

english, 1999

23

Acid-labile handles for Fmoc solid-phase synthesis of peptideN-alkylamides

Michael F. Songster, Josef Vágner, George Barany

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1996

Language:

english

File:

PDF, 400 KB

english, 1996

24

Solid-Phase Synthesis of Heterobivalent Ligands Targeted to Melanocortin and Cholecystokinin Receptors

Jatinder S. Josan, Josef Vagner, Heather L. Handl, Rajesh Sankaranarayanan, Robert J. Gillies, Victor J. Hruby

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2008

Language:

english

File:

PDF, 317 KB

english, 2008

25

Lanthanide-based time-resolved fluorescence of in cyto ligand–receptor interactions

Heather L Handl, Josef Vagner, Henry I Yamamura, Victor J Hruby, Robert J Gillies

Journal:

Analytical Biochemistry

Year:

2004

Language:

english

File:

PDF, 429 KB

english, 2004

26

Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of α-MSH

Josef Vagner, Heather L. Handl, Robert J. Gillies, Victor J. Hruby

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 169 KB

english, 2004

27

Phenolic acids and peroxidase activity in alfalfa (Medicago sativa) embryogenic cultures after ethephon treatment

Milena Cvikrová, Marie Hrubcová, Martin Vägner, Ivana Macháčková, Josef Eder

Journal:

Physiologia Plantarum

Year:

1994

Language:

english

File:

PDF, 696 KB

english, 1994

28

Solid-Phase Traceless Synthesis of Selected Nitrogen-Containing Heterocyclic Compounds. The Encore Technique for Directed Sorting of Modular Solid Support

Krchňák, Viktor, Smith, Jennifer, Vágner, Josef

Journal:

Collection of Czechoslovak Chemical Communications

Year:

2001

Language:

english

File:

PDF, 1.72 MB

english, 2001

29

New automatic control and scram system for the VVR-S reactor

Pavel Kovanic, Jaroslav Ryhl, Karel Vagner, Josef Teska

Journal:

Year:

1963

Language:

english

File:

PDF, 756 KB

english, 1963

30

Multiple continuous-flow solid-phase peptide synthesis Synthesis of an HIV antigenic peptide and its omission analogues

VIKTOR KRCHŇÁK, JOSEF VÁGNER, OTAKAR MACH

Journal:

Chemical Biology & Drug Design

Year:

1989

Language:

english

File:

PDF, 469 KB

english, 1989

31

Noninvasive continuous monitoring of solid-phase peptide synthesis by acid-base indicator

Viktor Krchňák, Josef Vágner, Michal Lebl

Journal:

Chemical Biology & Drug Design

Year:

1988

Language:

english

File:

PDF, 139 KB

english, 1988

32

Aggregation of resin-bound peptides during solid-phase peptide synthesis : Prediction of difficult sequences

VIKTOR KRCHŇÁK, ZUZKA FLEGELOVÁ, JOSEF VÁGNER

Journal:

Chemical Biology & Drug Design

Year:

1993

Language:

english

File:

PDF, 461 KB

english, 1993

33

Solid-phase peptide head-to-side chain cyclodimerization: Discovery of C2-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors

Alexander V. Mayorov, Minying Cai, Erin S. Palmer, Zhihua Liu, James P. Cain, Josef Vagner, Dev Trivedi, Victor J. Hruby

Journal:

Year:

2010

Language:

english

File:

PDF, 625 KB

english, 2010

34

Novel Toll-like Receptor 2 Ligands for Targeted Pancreatic Cancer Imaging and Immunotherapy

Huynh, Amanda Shanks, Chung, Woo Jin, Cho, Hyun-Il, Moberg, Valerie E., Celis, Esteban, Morse, David L., Vagner, Josef

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 467 KB

english, 2012

35

Synthesis and Characterization of a Melanoma-Targeted Fluorescence Imaging Probe by Conjugation of a Melanocortin 1 Receptor (MC1R) Specific Ligand

Tafreshi, Narges K., Huang, Xuan, Moberg, Valerie E., Barkey, Natalie M., Sondak, Vernon K., Tian, Haibin, Morse, David L., Vagner, Josef

Journal:

Bioconjugate Chemistry

Year:

2012

Language:

english

File:

PDF, 2.44 MB

english, 2012

36

Noninvasive continuous monitoring of solid-phase peptide synthesis by acid-base indicator

Krchňák, Viktor, Vágner, Josef, Šafář, Pavel, Lebl, Michal

Journal:

Collection of Czechoslovak Chemical Communications

Year:

1988

Language:

english

File:

PDF, 492 KB

english, 1988

37

Backbone Amide Linker (BAL) Strategy for Solid-Phase Synthesis of C-Terminal-Modified and Cyclic Peptides 1,2,3

Jensen, Knud J., Alsina, Jordi, Songster, Michael F., Vágner, Josef, Albericio, Fernando, Barany, George

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 289 KB

english, 1998

38

Synthesis and Characterization of Time-resolved Fluorescence Probes for Evaluation of Competitive Binding to Melanocortin Receptors

Alleti, Ramesh, Vagner, Josef, Dehigaspitiya, Dilani Chathurika, Moberg, Valerie E., Elshan, N.G.R.D., Tafreshi, Narges K., Brabez, Nabila, Weber, Craig S., Lynch, Ronald M., Hruby, Victor J., Gillies

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.10 MB

english, 2013

39

Development of Melanoma-Targeted Polymer Micelles by Conjugation of a Melanocortin 1 Receptor (MC1R) Specific Ligand

Barkey, Natalie M., Tafreshi, Narges K., Josan, Jatinder S., De Silva, Channa R., Sill, Kevin N., Hruby, Victor J., Gillies, Robert J., Morse, David L., Vagner, Josef

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 721 KB

english, 2011

40

Rigid Linkers for Bioactive Peptides

Vagner, Josef, Handl, Heather L., Monguchi, Yasunari, Jana, Umasish, Begay, Lucinda J., Mash, Eugene A., Hruby, Victor J., Gillies, Robert J.

Journal:

Bioconjugate Chemistry

Year:

2006

Language:

english

File:

PDF, 216 KB

english, 2006

41

Lanthanide Labeling of a Potent Protease Activated Receptor-2 Agonist for Time-Resolved Fluorescence Analysis

Hoffman, Justin, Flynn, Andrea N., Tillu, Dipti V., Zhang, Zhenyu, Patek, Renata, Price, Theodore J., Vagner, Josef, Boitano, Scott

Journal:

Bioconjugate Chemistry

Year:

2012

Language:

english

File:

PDF, 2.37 MB

english, 2012

42

Enzyme-Mediated Spatial Segregation on Individual Polymeric Support Beads: Application to Generation and Screening of Encoded Combinatorial Libraries

Josef Vágner, George Barany, Kit S. Lam, Viktor Krchn̆ák, Nikolai F. Sepetov, James A. Ostrem, Peter Strop and Michal Lebl

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.25 MB

english, 1996

43

Specificity and Mobility of Biomacromolecular, Multivalent Constructs for Cellular Targeting

Rosca, Elena V., Stukel, Jill M., Gillies, Robert J., Vagner, Josef, Caplan, Michael R.

Journal:

Biomacromolecules

Year:

2007

Language:

english

File:

PDF, 610 KB

english, 2007

44

Improving Metabolic Stability by Glycosylation: Bifunctional Peptide Derivatives That Are Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists

Yamamoto, Takashi, Nair, Padma, Jacobsen, Neil E., Vagner, Josef, Kulkarni, Vinod, Davis, Peg, Ma, Shou-wu, Navratilova, Edita, Yamamura, Henry I., Vanderah, Todd W., Porreca, Frank, Lai, Josephine, H

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 3.90 MB

english, 2009

45

Potent Agonists of the Protease Activated Receptor 2 (PAR 2 )

Boitano, Scott, Flynn, Andrea N., Schulz, Stephanie M., Hoffman, Justin, Price, Theodore J., Vagner, Josef

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.54 MB

english, 2011

46

Cell-Specific Targeting by Heterobivalent Ligands

Josan, Jatinder S., Handl, Heather L., Sankaranarayanan, Rajesh, Xu, Liping, Lynch, Ronald M., Vagner, Josef, Mash, Eugene A., Hruby, Victor J., Gillies, Robert J.

Journal:

Bioconjugate Chemistry

Year:

2011

Language:

english

File:

PDF, 4.26 MB

english, 2011

47

Design, Synthesis, and Validation of a Branched Flexible Linker for Bioactive Peptides

Bowen, Martina E., Monguchi, Yasunari, Sankaranarayanan, Rajesh, Vagner, Josef, Begay, Lucinda J., Xu, Liping, Jagadish, Bhumasamudram, Hruby, Victor J., Gillies, Robert J., Mash, Eugene A.

Journal:

Journal of Organic Chemistry

Year:

2007

Language:

english

File:

PDF, 193 KB

english, 2007

48

Synthesis and Evaluation of Bivalent NDP-α-MSH(7) Peptide Ligands for Binding to the Human Melanocortin Receptor 4 (hMC4R)

Handl, Heather L., Sankaranarayanan, Rajesh, Josan, Jatinder S., Vagner, Josef, Mash, Eugene A., Gillies, Robert J., Hruby, Victor J.

Journal:

Bioconjugate Chemistry

Year:

2007

Language:

english

File:

PDF, 500 KB

english, 2007

49

Structure–Activity Relationships of Cyclic Lactam Analogues of α-Melanocyte-Stimulating Hormone (α-MSH) Targeting the Human Melanocortin-3 Receptor

Mayorov, Alexander V., Cai, Minying, Palmer, Erin S., Dedek, Matthew M., Cain, James P., Van Scoy, April R., Tan, Bahar, Vagner, Josef, Trivedi, Dev, Hruby, Victor J.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 995 KB

english, 2008

50

Colour-Monitored Solid-Phase Multiple Peptide Synthesis under Low-Pressure Continuous-Flow Conditions. Synthesis of Medium-Size Peptides: The Propart of Human Procathepsin D and the Growth-Hormone Releasing Factor

Vágner, Josef, Krchňák, Viktor, Pícha, Josef, Píchová, Drahomíra, Fusek, Martin

Journal:

Collection of Czechoslovak Chemical Communications

Year:

1993

File:

PDF, 713 KB

1993